Endocrine Abstracts

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...